Endometrial dating noyes

20-Dec-2019 13:32

An endometrial biopsy that shows a difference of more than 2 days between the histologic dating and actual day after ovulation is considered to be ''out of phase''.But such p ET studies according to the Noyes criterion in hormone replacement cycle are lacking .

Important limitations are the lack of knowledge about the implantation process, including endometrial receptivity and lack of reliable diagnosis of receptivity.

The involvement of ENPP3 in embryo attachment was tested in an in vitro model for human embryo implantation.

Interestingly, there was high expression of ENPP3 m RNA in stroma but not protein.

The pathophysiology of recurrent pregnancy loss (RPL) is still unknown in 50% of the cases.

Herein we measure the expression of beta3 integrin subunit, a well-known implantation marker, in women with or without RPL and correlate it with the histological dating of the endometrial tissue.

Important limitations are the lack of knowledge about the implantation process, including endometrial receptivity and lack of reliable diagnosis of receptivity.The involvement of ENPP3 in embryo attachment was tested in an in vitro model for human embryo implantation.Interestingly, there was high expression of ENPP3 m RNA in stroma but not protein.The pathophysiology of recurrent pregnancy loss (RPL) is still unknown in 50% of the cases.Herein we measure the expression of beta3 integrin subunit, a well-known implantation marker, in women with or without RPL and correlate it with the histological dating of the endometrial tissue.Presence of N-glycosylated ENPP3 in receptive phase uterine fluid in women confirms its regulation by progesterone and makes it possible to use in a non-invasive test of endometrial receptivity.